Immunoinformatics Aided Prediction of Cytotoxic T Cell Epitope of Respiratory Syncytial Virus
Keywords:epitope based vaccine, RSV-F protein, CTL epitope, human respiratory syncytial virus, immunoinformatics
The Respiratory Syncytial Virus (RSV) poses the threat of lower respiratory tract infection to the infants as well as elderlies. As there is no licensed vaccine, alternative vaccine candidates like Epitope-based vaccines can be considered as a potential candidate. Being conserved among strains and reported to elicit cytotoxic T cell (CTL) response, the fusion glycoprotein of RSV (RSV-FP) is a first-rate target for epitope based vaccine designing. As RSV specific CD8+ CTLs are the central cell of viral clearance, the epitopes capable to generate CTL response are desirable. In this study, available immunoinformatics tools are utilized with a target to predict epitopes on the RSV-FP that elicit strong (CTL) responses. We report seven nine-mer peptides that bind strongly with 17 different HLA, have 100% sequence conservancy and is projected to provide 76.03% population coverage worldwide.
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