Fatty Acid Binding Protein 3 (FABP3) Deficiency Does Not Impact on Feto-Placental Morphometry and Fatty Acid Transporters in Mice

Authors

  • Ariful Islam* and Yuji Owada Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan.

Keywords:

FABP3, PUFA, placenta, trophoblast, morphometry

Abstract

In most mammals, proper placentation along with its morphology is critical for fetal development and pregnancy success. Fatty acid binding protein 3 (FABP3) has been shown to regulate the transportation of polyunsaturated fatty acid (PUFA) to the fetus, but its impact on placental morphology and genetic alteration of fatty acid transporters in trophoblast cells is still unknown. Using mice model we found Fabp3 deficiency does not affect the morphology of placenta along with the gene of fatty acid transporters. FABP3 deficiency was also found to have no impact on the morphology of human trophoblast cells (BeWo cells) in in vitro study. Fatty acid transporter genes were also remains unaltered after FABP3 knockdown. Our study suggests that placenta may conserve its morphology and genetics although it has PUFAs deficiency.

Citation
This paper has been cited by the following papers:
1. FABP7 protects astrocytes against ROS toxicity via lipid droplet formation

Published

2015-07-01

How to Cite

Ariful Islam* and Yuji Owada (2015) “Fatty Acid Binding Protein 3 (FABP3) Deficiency Does Not Impact on Feto-Placental Morphometry and Fatty Acid Transporters in Mice”, Bioresearch Communications-(BRC). Dhaka, Bangladesh, 1(2), pp. 57-61. Available at: http://bioresearchcommunications.com/index.php/brc/article/view/46 (Accessed: 29November2020).

Issue

Section

Original Article