DNA Polymorphisms in the lactoglobulin ans K-casein Gense Associated with Milk Production Traits on Dairy Cattle

Authors

  • M. A. Alim*, Dongxiao Sun, Yi Zhang, Yuan Zhang, Qin Zhang and Lin Liu Division of Animal Biotechnology, National Institute of Biotechnology, Ganakbari, Asulia, Savar, Dhaka-1349

Keywords:

Single Nucleotide Polymorphism (SNP), dairy cattle

Abstract

In recent years, the polymorphism of the milk proteins has been used as marker systems in modern animal breeding programmes. The current study was designed to evaluate significant associations between single nucleotide polymorphisms (SNPs) and milk production traits in Chinese Holstein cows.  In this study, we detected the polymorphism of B-lactoglobulin and k–casein genes by Matrix-assisted laser desorption/ ionization time of flight mass spectrometry (MALDI-TOF) and DNA sequencing methods in 752 individuals from Chinese Holstein cattle breeds. A single nucleotide polymorphism (g.1810C>T) in exon III in B-lactoglobulin gene and two single nucleotide polymorphisms (g.10888T>C and g.12703G>T) in exon IV and intron IV in k– casein gene were detected. Polymorphism g.10888T>C was predicted to result in an amino acid replacement from threonine (ACC) to isoleucine (ATC) in the k–casein protein whereas polymorphism g.1810C>T was predicted to silent mutation (asparagines>asparagines) in B-lactoglobulin protein. The results revealed the significant effects (P<0.05) of all identified SNPs of B-lactoglobulin and k–casein genes on the milk production traits in Chinese Holstein. Our result demonstrated that the B-lactoglobulin and k–casein genes possibly contributed to conducting association analysis and can be recognized as genetic marker

 

Citation
This paper has been cited by the following papers:
1. https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12922
2. Relationships between milk protein polymorphisms and production traits in cattle: a systematic review and meta-analysis
3. http://repository.lsmuni.lt/handle/1/60458
4. https://www.lsmuni.lt/cris/handle/20.500.12512/97784 

5. https://llufb.llu.lv/conference/lidzsvar_lauksaim/2016/Latvia-lidzsvarota-lauksaimnieciba2016-178-183.pdf

6. https://onlinelibrary.wiley.com/doi/abs/10.1111/age.12922

Published

2015-07-01

How to Cite

M. A. Alim*, Dongxiao Sun, Yi Zhang, Yuan Zhang, Qin Zhang and Lin Liu (2015) “DNA Polymorphisms in the lactoglobulin ans K-casein Gense Associated with Milk Production Traits on Dairy Cattle”, Bioresearch Communications-(BRC). Dhaka, Bangladesh, 1(2), pp. 82-86. Available at: http://bioresearchcommunications.com/index.php/brc/article/view/169 (Accessed: 29November2020).

Issue

Section

Original Article