STR Data for the AmpFlSTR SGM Plus Loci From Three Ethnic Populations of Bangladesh and Their Genetic Affinities With Other Populations
Md. Ismail Hosen1, Md. Mahamud Hasan2, Tania Hossain2, Ashish K. Majumder2, Abu Sufian2, Pilu Momtaz2 and Sharif Akhteruzzaman3*
1Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh. 2National Forensic DNA Profiling laboratory,
Dhaka Medical College, Dhaka-1000, Bangladesh.
*3Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka-1000, Bangladesh
ABSTRACT: Allele frequency distribution of 10 autosomal STR loci, D3S1358, vWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, TH01, and FGA was studied
in three ethnic populations such as, Garo, Marma and Rakhains living in different parts of Bangladesh. There were no significant deviations from Hardy–Weinberg
equilibrium in any of the loci after Bonferroni correction (p < 0.005) in the studied populations. Forensic efficiency parameters like observed and expected
heterozygosity (Ho and He), power of discrimination (PD), power of exclusion (PE), probability of match (PM) and typical paternity index (TPI) were studied
for these loci. The combined power of discrimination and combined power of exclusion were >0.9999999999 and >0.9995 respectively in all the populations.
A neighbor-joining tree constructed based on pair-wise Nei’s genetic distance by comparing allele frequencies for the 10 STR loci with two other ethnic
populations and mainstream Bangladeshi population is also presented.
KEYWORDS: Short tandem repeats, Allele frequency, Heterozygosity, Power of discrimination, Neighbor-joining tree