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Cataractostatic Activity of Drynaria Quercifolia Tuber Extract


Md. Miraj Kobad Chowdhury, Md. Jakir Hossain, M Aftab Uddin*

Advanced Biotechnology Laboratory, Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka-1000, Bangladesh.

ABSTRACT: The cataractostatic activity of methanolic and ethylacetate extracts of Drynaria quercifolia tuber were evaluated here as a prospective treatment for lens cataracts. Glucose-induced cataract formed in isolated goat lenses in vitro was used as a model in this investigation. When tested with extracts, it was observed that the ethylacetate extracts of the tuber was able to inhibit cataractogenesis when the lenses were treated at a final concentration of 20 g/ml. However, methanolic extract of the tuber showed a moderate anticataract activity at 80 g/ml concentration. When justified quantitatively, the cataract formation was inhibited 51.61±9.68% by methanolic extract at 80 g/ml. On the contrary, the ethylacetate extract could inhibit cataract formation by 62.37±15.24% at 20 g/ml and 100.00±3.23% at 80 g/ml. These data indicated that, the ethylacetate extract of Drynaria quercifolia tuber is a potent cataractostatic agent and may be able to prevent diabetic cataract.

KEYWORDS: Cataractostatic activity, Drynaria quercifolia, goat lens, in vitro.

CORRESPONDENCE:M Aftab Uddin, E-mail: draftabu@gmail.com

 

 
 
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