Absorption of Water and Electrolytes from a Liposome Based Oral Rehydration Solution: An in vivo Perfusion Study on Mucosal Injured Small Intestine Rat Model
Rifat Faruqui1&2, Hamida Khanum1, Pradip Kumar Bardhan2 and Cheryl Mitchell3
1Department of Zoology, University of Dhaka. 2International Centre for Diarrhoeal Disease Research, 3Bangladesh CRM Corporation, USA.
ABSTRACT: In the present study, rats were used to identify the efficacy of three types of Oral Rehydration Solutions (ORSs); standard ORS (S-ORS), hydrolyzed starch ORS (HS-ORS) and Liposomal ORS (Lipo-ORS) using an in vivo perfusion technique on a 5-Fluorouracil mediated mucosal injured rat small intestine model. This study comparess the absorption of electrolytes (Na+, K+, Cl-) and water from these three types of ORSs and compared among these substances from each other. It was found that liposome based ORS is associated with significantly higher Na+, K+, Cl- and water absorption compared to hydrolyzed starch ORS or standard ORS. It can be concluded that liposomes enhance more electrolyte absorption from a carbohydrate electrolytes solution in mucosal injured small intestine of rat than normal small intestine of rats. These findings underscore the potential clinical importance of liposome based electrolyte solution for rehydration.
KEYWORDS: Rat, Liposome based ORS, perfusion Study, mucosal injured intestine of rat, 5-Fluorouracil.
CORRESPONDENCE: Hamida Khanum. Email Address: firstname.lastname@example.org