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Network and pathway analysis for Cesium in Homo sapiens


Md. Taif Ali1,2, Saiful Arefin Sazed3 ,Parag Palit2 , Md. Abu Sayed4 , Md. Ashraful Alam5*

1Department of Biochemistry & Molecular Biology, University of Dhaka, Dhaka, Bangladesh, 2Division of Computer-Aided Drug Design, BICCB, Green Research Centre, 38 Green Road West, Dhaka-1205, Bangladesh, 3Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh, 4Department of Biochemistry and Molecular Biology, Hajee Mohammad Danesh Science and Technology University, Dinajpuir-5200, Bangladesh, 5Faculty of Science and Engineering, Iwate University, Japan

ABSTRACT: Cesium is an alkali metal whose physiological roles and toxic effects have not been reported until date. In contrast, radio cesium has long lasting half-life of at least 30 years which can be toxic and hazardous to health. Radio isotope of cesium is usually used for nuclear energy production and recently incidence of nuclear power plant in Japan caused havoc to their local environment. To elucidate the possible interactions of cesium with proteins or genes in human body, we have applied some recently developed computational tools in this present study. Our results show that cesium has either some positive or negative interactions with 10 human proteins and subsequently these 10 proteins have been found to interact with 99 other human proteins through the application of bioinformatics tools. All of these proteins are involved in cellular, molecular and biological functions in human body. We need to conduct further study to know the specific functions of all these proteins so that further experiments can be conducted in laboratory to find out the possible effects of radio-cesium in rat models.

KEYWORDS: Cesium, cellular component, gene ontology, human health, proteins

CORRESPONDENCE: Md. Ashraful Alam. Email Address: sdashraf84@yahoo.com

 

 
 
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